October 7, 2022

Why some kids’ immune systems don’t respond to bronchiolitis

Madrid, Sept. 23 (EFE) — Spanish researchers have discovered why some children’s immune systems fail to respond to bronchiolitis or wheezing, conditions that can become chronic and lead to other types of illness, such as asthma.

The reason: the reduced presence of a biomarker (the microRNA called miR-146a-5p) in the airways of infants and children with these conditions, which makes these patients unable to control the inflammation generated in response to the infection. and would explain the chronicle of these pictures.

The study, the results of which were published in the journal Cells, was conducted by a team from the Biomedical Research Center for Respiratory Diseases Network (CIBERES) and the Fundación Jiménez Díaz Health Research Institute (IIS-FJD), in collaboration with researchers from the Hospital Severo Ochoa, of the Hospital de la Paz, the Alfonso X el Sabio University and the National Center for Microbiology.

The Carlos III of Madrid.

The research team focused on evaluating the presence of this biomarker in infants with bronchiolitis and wheezing, which is often associated with anti-inflammatory properties, to study its possible role in these pathologies.

To do this, they performed molecular and cellular biology techniques using nasopharyngeal aspirate samples from infants with bronchiolitis (both during the disease and after it was overcome), from children with wheezing, and from healthy children of the same age who were in hospitals. recruited from the study.

In addition, they used in vitro models of small airway epithelial cells from healthy individuals.

In particular, “a reduction in the expression of this biomarker was observed in the airways of infants with bronchiolitis and in samples from children who experienced wheezing, compared to controls,” detailed Victoria del Pozo, CIBERES group head at the Jiménez Díaz Foundation Health Research Institute (IIS-FJD).

In the children who overcame bronchiolitis, the presence of this marker was elevated, “although without reaching the control levels of healthy children, and may be key in the chronicity of the inflammation,” the researcher explained.

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